The Philippine Science High School has a core curriculum which aims to develop the scholar in all disciplines. Students experience a common freshman year, with a demanding English and Mathematics curriculum, and exposure to Earth Science and Technology Preparation. The students then go through a process that allows them to follow either a science stream or a technology stream.
The streaming courses are given through electives in the second through fourth year. The core courses are taken by all students.
The core curriculum is packed with science and mathematics courses, allowing the student to maximize their potential intellectual skills. This is balanced by rich humanities course offerings which foster the full growth of each individual personality.
The science and mathematics subjects are generally advanced. Each year starting in the second year, the students take Biology, Chemistry and Physics as separate subjects. Computer Science is offered in all year levels.